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Evaluation of C-peptide in Type 2 Diabetic Patients in Douala Cameroon: C-peptide Correlation with Arterial Hypertension and the Types of Treatment Administered

Received: 17 August 2021     Accepted: 16 October 2021     Published: 28 October 2021
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Abstract

Introduction: C-peptide is the best indicator of endogenous insulin secretion; it makes it possible to optimize the treatment, and to prevent the occurrence and the evolution of the damages resulting from type 2 diabetes. The present study reports the variation of C-peptide levels according to the types of treatment administrated and the high blood pressure in type 2 diabetes in two hospitals (General Hospital and Gyneco-Obstetric and Pediatric Hospital) in the city of Douala Cameroon. Methodology Over a period of 9 months (from October, 1st 2017 to June, 30th 2018), we conducted an analytical cross-sectional study involving subjects with type 2 diabetes regularly monitored at the General Hospital and Gyneco-Obstetric and Pediatric Hospital of Douala Cameroon. Inclusion criteria we included any subject whose diagnosis of type 2 diabetes was mentioned in the medical file. The fasting C-peptide assays were performed according to the principle of electrochemiluminescence. The ANOVA and PEARSON tests were use to investigate on the one hand the correlations between the C peptide levels and the types of treatment administered, and on the other hand between the C-peptide levels and arterial hypertension. The significant threshold was set at P <0.05. Results: Our population, made up of 90 subjects, had a mean age of 58±12.31 years, sex ratio 0.8 in favor of women. The mean duration of diabetes was 8.71±6, 94 years, we had 30 hypertensive subjects under hypertensive treatment, the mean C-peptide levels was 2.50±1.68ng / ml. We found that C-peptide levels increased with patient ages (P=0.004), a significant correlation between C-peptide levels and high blood pressure (P=0.022), and C-Peptide levels varied significantly depending on the type of treatment (P=0.04). Conclusion: Type 2 diabetic patients on oral antidiabetic drugs, and having a low level of C-peptide, should undergo a modification of their treatment by the addition (or the replacement) of insulin, for better glycemic control. Diabetic and hypertensive patients are more exposed to micro and macrovascular complications. Hence the importance of instituting more assiduous blood pressure control, appropriate hypotensive therapy, as well as training patients in self-management and prevention of the onset of complications related to diabetes.

Published in International Journal of Diabetes and Endocrinology (Volume 6, Issue 4)
DOI 10.11648/j.ijde.20210604.12
Page(s) 131-133
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

C-peptide, Type 2 Diabetes, Hypertension, Douala

References
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[5] Xuanqian Xie, Hindrik Vondeling. Cost-utility Analysis of Intensive Blood Glucose Control with Metformin versus Usual Care in Overweight Type 2 Diabetes Mellitus Patients in Beijing, PR China. Value in Health 11, S23-S32, 2008.
[6] Emma Leighton, Christopher AR Sainsbury, Gregory C. Jones. A practical Reviiew of C-peptide Testing in Diabetes. Diabetes therapy 8 (3), 475-487, 2017.
[7] Beliakin SA, Serebrennikov VN, Shklovskii BL, Patsenko MB. C-peptide as an early diagnostic of metabolic syndrome and indicator of cardiovascular disease in patients with type 2 diabetes mellitus. Voen Med Zh 2014; 335 (10): 46-9.
[8] AG Jones, AT Hattersley. Diabetic medicine 30 (7), 803-817, 2013.
[9] www.roche.com: notice C-peptide Elecsys 2013-11, V 9.0 English.
[10] Sari R, Balci MK. Relationship between C peptide and chronic complications in type-2 diabetes mellitus. J Natl Med Assoc 2005; 97: 1113–1118.
[11] Inukai T, Matsutomo R, Tayama K, Aso Y, Takemura Y. Relation between the serum level of C-peptide and risk factors for coronary heart disease and diabetic microangiopathy in patients with type-2 diabetes mellitus. ExpClinEndocrinol Diabetes 1999; 107: 40–45.
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[18] Johnny Ludvigsson, Annelie Carlsson, Gun Forsander, Sten Ivarsson, I. Kkockum, Ake. C-peptide in the Classification of Diabtes in Children and Adelescents. Pediatric Diabetes 13 (1), 45-50, 2012.
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  • APA Style

    Manta Diane, Mbango-Ekouta Noel Désirée, Nda Mefo'o Jean Pierre, Assiene Oyong Damase Serge, Eloumou Bagnaka Servais, et al. (2021). Evaluation of C-peptide in Type 2 Diabetic Patients in Douala Cameroon: C-peptide Correlation with Arterial Hypertension and the Types of Treatment Administered. International Journal of Diabetes and Endocrinology, 6(4), 131-133. https://doi.org/10.11648/j.ijde.20210604.12

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    ACS Style

    Manta Diane; Mbango-Ekouta Noel Désirée; Nda Mefo'o Jean Pierre; Assiene Oyong Damase Serge; Eloumou Bagnaka Servais, et al. Evaluation of C-peptide in Type 2 Diabetic Patients in Douala Cameroon: C-peptide Correlation with Arterial Hypertension and the Types of Treatment Administered. Int. J. Diabetes Endocrinol. 2021, 6(4), 131-133. doi: 10.11648/j.ijde.20210604.12

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    AMA Style

    Manta Diane, Mbango-Ekouta Noel Désirée, Nda Mefo'o Jean Pierre, Assiene Oyong Damase Serge, Eloumou Bagnaka Servais, et al. Evaluation of C-peptide in Type 2 Diabetic Patients in Douala Cameroon: C-peptide Correlation with Arterial Hypertension and the Types of Treatment Administered. Int J Diabetes Endocrinol. 2021;6(4):131-133. doi: 10.11648/j.ijde.20210604.12

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  • @article{10.11648/j.ijde.20210604.12,
      author = {Manta Diane and Mbango-Ekouta Noel Désirée and Nda Mefo'o Jean Pierre and Assiene Oyong Damase Serge and Eloumou Bagnaka Servais and Adiogo Dieudonné},
      title = {Evaluation of C-peptide in Type 2 Diabetic Patients in Douala Cameroon: C-peptide Correlation with Arterial Hypertension and the Types of Treatment Administered},
      journal = {International Journal of Diabetes and Endocrinology},
      volume = {6},
      number = {4},
      pages = {131-133},
      doi = {10.11648/j.ijde.20210604.12},
      url = {https://doi.org/10.11648/j.ijde.20210604.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijde.20210604.12},
      abstract = {Introduction: C-peptide is the best indicator of endogenous insulin secretion; it makes it possible to optimize the treatment, and to prevent the occurrence and the evolution of the damages resulting from type 2 diabetes. The present study reports the variation of C-peptide levels according to the types of treatment administrated and the high blood pressure in type 2 diabetes in two hospitals (General Hospital and Gyneco-Obstetric and Pediatric Hospital) in the city of Douala Cameroon. Methodology Over a period of 9 months (from October, 1st 2017 to June, 30th 2018), we conducted an analytical cross-sectional study involving subjects with type 2 diabetes regularly monitored at the General Hospital and Gyneco-Obstetric and Pediatric Hospital of Douala Cameroon. Inclusion criteria we included any subject whose diagnosis of type 2 diabetes was mentioned in the medical file. The fasting C-peptide assays were performed according to the principle of electrochemiluminescence. The ANOVA and PEARSON tests were use to investigate on the one hand the correlations between the C peptide levels and the types of treatment administered, and on the other hand between the C-peptide levels and arterial hypertension. The significant threshold was set at P Results: Our population, made up of 90 subjects, had a mean age of 58±12.31 years, sex ratio 0.8 in favor of women. The mean duration of diabetes was 8.71±6, 94 years, we had 30 hypertensive subjects under hypertensive treatment, the mean C-peptide levels was 2.50±1.68ng / ml. We found that C-peptide levels increased with patient ages (P=0.004), a significant correlation between C-peptide levels and high blood pressure (P=0.022), and C-Peptide levels varied significantly depending on the type of treatment (P=0.04). Conclusion: Type 2 diabetic patients on oral antidiabetic drugs, and having a low level of C-peptide, should undergo a modification of their treatment by the addition (or the replacement) of insulin, for better glycemic control. Diabetic and hypertensive patients are more exposed to micro and macrovascular complications. Hence the importance of instituting more assiduous blood pressure control, appropriate hypotensive therapy, as well as training patients in self-management and prevention of the onset of complications related to diabetes.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - Evaluation of C-peptide in Type 2 Diabetic Patients in Douala Cameroon: C-peptide Correlation with Arterial Hypertension and the Types of Treatment Administered
    AU  - Manta Diane
    AU  - Mbango-Ekouta Noel Désirée
    AU  - Nda Mefo'o Jean Pierre
    AU  - Assiene Oyong Damase Serge
    AU  - Eloumou Bagnaka Servais
    AU  - Adiogo Dieudonné
    Y1  - 2021/10/28
    PY  - 2021
    N1  - https://doi.org/10.11648/j.ijde.20210604.12
    DO  - 10.11648/j.ijde.20210604.12
    T2  - International Journal of Diabetes and Endocrinology
    JF  - International Journal of Diabetes and Endocrinology
    JO  - International Journal of Diabetes and Endocrinology
    SP  - 131
    EP  - 133
    PB  - Science Publishing Group
    SN  - 2640-1371
    UR  - https://doi.org/10.11648/j.ijde.20210604.12
    AB  - Introduction: C-peptide is the best indicator of endogenous insulin secretion; it makes it possible to optimize the treatment, and to prevent the occurrence and the evolution of the damages resulting from type 2 diabetes. The present study reports the variation of C-peptide levels according to the types of treatment administrated and the high blood pressure in type 2 diabetes in two hospitals (General Hospital and Gyneco-Obstetric and Pediatric Hospital) in the city of Douala Cameroon. Methodology Over a period of 9 months (from October, 1st 2017 to June, 30th 2018), we conducted an analytical cross-sectional study involving subjects with type 2 diabetes regularly monitored at the General Hospital and Gyneco-Obstetric and Pediatric Hospital of Douala Cameroon. Inclusion criteria we included any subject whose diagnosis of type 2 diabetes was mentioned in the medical file. The fasting C-peptide assays were performed according to the principle of electrochemiluminescence. The ANOVA and PEARSON tests were use to investigate on the one hand the correlations between the C peptide levels and the types of treatment administered, and on the other hand between the C-peptide levels and arterial hypertension. The significant threshold was set at P Results: Our population, made up of 90 subjects, had a mean age of 58±12.31 years, sex ratio 0.8 in favor of women. The mean duration of diabetes was 8.71±6, 94 years, we had 30 hypertensive subjects under hypertensive treatment, the mean C-peptide levels was 2.50±1.68ng / ml. We found that C-peptide levels increased with patient ages (P=0.004), a significant correlation between C-peptide levels and high blood pressure (P=0.022), and C-Peptide levels varied significantly depending on the type of treatment (P=0.04). Conclusion: Type 2 diabetic patients on oral antidiabetic drugs, and having a low level of C-peptide, should undergo a modification of their treatment by the addition (or the replacement) of insulin, for better glycemic control. Diabetic and hypertensive patients are more exposed to micro and macrovascular complications. Hence the importance of instituting more assiduous blood pressure control, appropriate hypotensive therapy, as well as training patients in self-management and prevention of the onset of complications related to diabetes.
    VL  - 6
    IS  - 4
    ER  - 

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Author Information
  • Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon

  • Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon

  • Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon

  • Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon

  • Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon

  • Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon

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