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Determining Factors of Mortality by Ketoacidosis as Seen in the Unit of Endocrinology at Joseph Raseta Befelatanana Teaching Hospital, Antananarivo-Madagascar

Received: 8 June 2022     Accepted: 21 June 2022     Published: 30 June 2022
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Abstract

Introduction: Ketoacidosis is one of the acute metabolic complications of diabetes. It is more common and has a higher death rate in sub-Saharan Africa. To our knowledge, there are very few studies done on diabetic ketoacidosis in Madagascar. The aim of our study was to determine the hospital prevalence of diabetic ketoacidosis, to describe their epidemioclinical features as well as to look for determinants of hospital mortality in patients with ketoacidosis in the unit of endocrinology at Joseph Raseta Befelatanana University Hospital, Antananarivo. Methods: This is a descriptive retrospective study of diabetics admitted to this unit for ketoacidosis, over a period of 15 months (from January 1, 2017, to March 30, 2018). Results: Sixty-four patients were selected for the study. The hospital prevalence of ketoacidosis was 5.61%. The mean age of the patients was 46.3 years with a sex ratio of 0.94. Type 2 diabetes predominated in terms of frequency (62.5%). In 37.5% of cases, ketoacidosis was the inaugural diabetes. For patients known to be diabetic before admission, infection was the most common etiologic factor (48.44%), followed by discontinuation of treatment (31.25%). The death rate was 3.13%. Epidemioclinical variables: age [50-60 years], disturbance of consciousness, Glasgow scale < 10 as well as paraclinical variables: glycemia > 500 mg/dl, hyperkalaemia and ketonuria at 4+ at entry are determinants of mortality. Conclusion: Ketoacidosis exposes people to mortality, the rate of which is not negligible. There are determinants of hospital mortality from this complication of diabetes. The therapeutic education of patients and the improvement of screening tools are very important for prevention.

Published in International Journal of Diabetes and Endocrinology (Volume 7, Issue 2)
DOI 10.11648/j.ijde.20220702.14
Page(s) 43-49
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Diabetes Mellitus, Ketoacidosis, Madagascar, Mortality

References
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Cite This Article
  • APA Style

    Thierry Razanamparany, Sitraka Angelo Raharinavalona, Haritsiky Robertini Ramalanjaona, Rija Eric Raherison, Miora Maeva Arielle Andrianiaina, et al. (2022). Determining Factors of Mortality by Ketoacidosis as Seen in the Unit of Endocrinology at Joseph Raseta Befelatanana Teaching Hospital, Antananarivo-Madagascar. International Journal of Diabetes and Endocrinology, 7(2), 43-49. https://doi.org/10.11648/j.ijde.20220702.14

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    ACS Style

    Thierry Razanamparany; Sitraka Angelo Raharinavalona; Haritsiky Robertini Ramalanjaona; Rija Eric Raherison; Miora Maeva Arielle Andrianiaina, et al. Determining Factors of Mortality by Ketoacidosis as Seen in the Unit of Endocrinology at Joseph Raseta Befelatanana Teaching Hospital, Antananarivo-Madagascar. Int. J. Diabetes Endocrinol. 2022, 7(2), 43-49. doi: 10.11648/j.ijde.20220702.14

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    AMA Style

    Thierry Razanamparany, Sitraka Angelo Raharinavalona, Haritsiky Robertini Ramalanjaona, Rija Eric Raherison, Miora Maeva Arielle Andrianiaina, et al. Determining Factors of Mortality by Ketoacidosis as Seen in the Unit of Endocrinology at Joseph Raseta Befelatanana Teaching Hospital, Antananarivo-Madagascar. Int J Diabetes Endocrinol. 2022;7(2):43-49. doi: 10.11648/j.ijde.20220702.14

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  • @article{10.11648/j.ijde.20220702.14,
      author = {Thierry Razanamparany and Sitraka Angelo Raharinavalona and Haritsiky Robertini Ramalanjaona and Rija Eric Raherison and Miora Maeva Arielle Andrianiaina and Tsikinirina Valisoa Randrianomanana and Fenitrasoa Randrianarizao and Andrianirina Dave Patrick Rakotomalala and Hanta Marie Danielle Vololontiana and Radonirina Lazasoa Andrianasolo},
      title = {Determining Factors of Mortality by Ketoacidosis as Seen in the Unit of Endocrinology at Joseph Raseta Befelatanana Teaching Hospital, Antananarivo-Madagascar},
      journal = {International Journal of Diabetes and Endocrinology},
      volume = {7},
      number = {2},
      pages = {43-49},
      doi = {10.11648/j.ijde.20220702.14},
      url = {https://doi.org/10.11648/j.ijde.20220702.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijde.20220702.14},
      abstract = {Introduction: Ketoacidosis is one of the acute metabolic complications of diabetes. It is more common and has a higher death rate in sub-Saharan Africa. To our knowledge, there are very few studies done on diabetic ketoacidosis in Madagascar. The aim of our study was to determine the hospital prevalence of diabetic ketoacidosis, to describe their epidemioclinical features as well as to look for determinants of hospital mortality in patients with ketoacidosis in the unit of endocrinology at Joseph Raseta Befelatanana University Hospital, Antananarivo. Methods: This is a descriptive retrospective study of diabetics admitted to this unit for ketoacidosis, over a period of 15 months (from January 1, 2017, to March 30, 2018). Results: Sixty-four patients were selected for the study. The hospital prevalence of ketoacidosis was 5.61%. The mean age of the patients was 46.3 years with a sex ratio of 0.94. Type 2 diabetes predominated in terms of frequency (62.5%). In 37.5% of cases, ketoacidosis was the inaugural diabetes. For patients known to be diabetic before admission, infection was the most common etiologic factor (48.44%), followed by discontinuation of treatment (31.25%). The death rate was 3.13%. Epidemioclinical variables: age [50-60 years], disturbance of consciousness, Glasgow scale  500 mg/dl, hyperkalaemia and ketonuria at 4+ at entry are determinants of mortality. Conclusion: Ketoacidosis exposes people to mortality, the rate of which is not negligible. There are determinants of hospital mortality from this complication of diabetes. The therapeutic education of patients and the improvement of screening tools are very important for prevention.},
     year = {2022}
    }
    

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  • TY  - JOUR
    T1  - Determining Factors of Mortality by Ketoacidosis as Seen in the Unit of Endocrinology at Joseph Raseta Befelatanana Teaching Hospital, Antananarivo-Madagascar
    AU  - Thierry Razanamparany
    AU  - Sitraka Angelo Raharinavalona
    AU  - Haritsiky Robertini Ramalanjaona
    AU  - Rija Eric Raherison
    AU  - Miora Maeva Arielle Andrianiaina
    AU  - Tsikinirina Valisoa Randrianomanana
    AU  - Fenitrasoa Randrianarizao
    AU  - Andrianirina Dave Patrick Rakotomalala
    AU  - Hanta Marie Danielle Vololontiana
    AU  - Radonirina Lazasoa Andrianasolo
    Y1  - 2022/06/30
    PY  - 2022
    N1  - https://doi.org/10.11648/j.ijde.20220702.14
    DO  - 10.11648/j.ijde.20220702.14
    T2  - International Journal of Diabetes and Endocrinology
    JF  - International Journal of Diabetes and Endocrinology
    JO  - International Journal of Diabetes and Endocrinology
    SP  - 43
    EP  - 49
    PB  - Science Publishing Group
    SN  - 2640-1371
    UR  - https://doi.org/10.11648/j.ijde.20220702.14
    AB  - Introduction: Ketoacidosis is one of the acute metabolic complications of diabetes. It is more common and has a higher death rate in sub-Saharan Africa. To our knowledge, there are very few studies done on diabetic ketoacidosis in Madagascar. The aim of our study was to determine the hospital prevalence of diabetic ketoacidosis, to describe their epidemioclinical features as well as to look for determinants of hospital mortality in patients with ketoacidosis in the unit of endocrinology at Joseph Raseta Befelatanana University Hospital, Antananarivo. Methods: This is a descriptive retrospective study of diabetics admitted to this unit for ketoacidosis, over a period of 15 months (from January 1, 2017, to March 30, 2018). Results: Sixty-four patients were selected for the study. The hospital prevalence of ketoacidosis was 5.61%. The mean age of the patients was 46.3 years with a sex ratio of 0.94. Type 2 diabetes predominated in terms of frequency (62.5%). In 37.5% of cases, ketoacidosis was the inaugural diabetes. For patients known to be diabetic before admission, infection was the most common etiologic factor (48.44%), followed by discontinuation of treatment (31.25%). The death rate was 3.13%. Epidemioclinical variables: age [50-60 years], disturbance of consciousness, Glasgow scale  500 mg/dl, hyperkalaemia and ketonuria at 4+ at entry are determinants of mortality. Conclusion: Ketoacidosis exposes people to mortality, the rate of which is not negligible. There are determinants of hospital mortality from this complication of diabetes. The therapeutic education of patients and the improvement of screening tools are very important for prevention.
    VL  - 7
    IS  - 2
    ER  - 

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Author Information
  • Faculty of Medicine, University of Antananarivo, Antananarivo, Madagascar

  • Facultyof Medicine, University of Antananarivo, Antananarivo, Madagascar

  • Facultyof Medicine, University of Antananarivo, Antananarivo, Madagascar

  • Faculty of Medicine, University of Antananarivo, Antananarivo, Madagascar

  • Faculty of Medicine, University of Antananarivo, Antananarivo, Madagascar

  • Faculty of Medicine, University of Antananarivo, Antananarivo, Madagascar

  • Unit of Endocrinology, Joseph Raseta Befelatanana Teaching Hospital, Antananarivo, Madagascar

  • Faculty of Medicine, University of Antananarivo, Antananarivo, Madagascar

  • Facultyof Medicine, University of Antananarivo, Antananarivo, Madagascar

  • Faculty of Medicine, University of Antananarivo, Antananarivo, Madagascar

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